Author

J. Hatcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Research Focus:phylogenetics / evolution· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

A. T. Ortiz· 1 shared B. E. A. Poblano· 1 shared B. Faezov· 1 shared B. J. Groendyke· 1 shared C. Williams· 1 shared D. K. Nomura· 1 shared E. S. Fischer· 1 shared F. A. Gowans· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperEvolutionary Biology

A. T. Ortiz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin

F. A. Gowans, N. Forte, J. Hatcher, O. W. Huang, Y. Wang, B. E. A. Poblano, I. E. Wertz, D. K. Nomura

This paper identifies a covalent degrader, EN83, that targets and degrades β-catenin by covalently binding to four cysteine residues, demonstrating a strategy to overcome the 'undruggable' challenge of transcription factors.

bioRxiv · Oct 31, 2023Biochemistry

Within-host diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks

A. T. Ortiz, M. Kendall, N. Storey, J. Hatcher, H. Dunn, S. Roy, R. Williams, C. Williams, R. A. Goldstein, X. Didelot, K. Harris, J. Breuer, L. Grandjean

This study shows that incorporating within-host genetic diversity improves phylogenetic and transmission reconstruction of SARS-CoV-2 outbreaks.

bioRxiv · Jun 7, 2022Evolutionary Biology

Development and utility of a PAK1-selective degrader

H.-Y. Chow, S. Karchugina, B. J. Groendyke, S. Toenjes, J. Hatcher, K. A. Donovan, E. S. Fischer, G. Abalakov, B. Faezov, R. L. Dunbrack, N. S. Gray, J. Chernoff

This study develops a PAK1-selective degrader, BJG-05-039, which shows enhanced anti-proliferative effects compared to the parent inhibitor NVS-PAK1-1 in PAK1-dependent cell lines.

bioRxiv · May 12, 2022Cancer Biology