Author

O. W. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

I. E. Wertz· 2 shared A. Osa· 1 shared B. E. A. Poblano· 1 shared D. K. Nomura· 1 shared D. Nomura· 1 shared F. A. Gowans· 1 shared J. Hatcher· 1 shared N. Forte· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

I. E. Wertz

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Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivOct 31, 2023

Covalent Degrader of the Oncogenic Transcription Factor β-Catenin

F. A. Gowans, N. Forte, J. Hatcher…·D. K. Nomura

This paper identifies a covalent degrader, EN83, that targets and degrades β-catenin by covalently binding to four cysteine residues, demonstrating a strategy to overcome the 'undruggable' challenge of transcription factors.

DOI 10.1021/jacs.4c05174

humanproteomics

𝕏 PostBluesky

BiochemistrybioRxivOct 20, 2023

Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation

S. H. Hong, A. Osa, O. W. Huang…·D. Nomura

This study identifies a covalent recruiter against SKP1 for PROTAC-based protein degradation, demonstrating its efficacy in degrading BRD4 and androgen receptor via the SCF complex.

DOI 10.1021/acschembio.3c00642

proteomicsexperimental assay

𝕏 PostBluesky