Author

F. A. Scheeren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

C. G. Figdor· 2 shared C. M. Le Gall· 2 shared D. van Dalen· 2 shared M. Verdoes· 2 shared A. Cammarata· 1 shared A. Cevirgel· 1 shared A. E. H. Bentlage· 1 shared A. F. El Hebieshy· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersBiochemistry

C. G. Figdor

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Malaria parasite evades mosquito immunity by glutaminyl cyclase mediated protein modification

S. K. Kolli, A. Molina-Cruz, T. Araki, F. J. A. v. Geurten, J. Ramesar, S. Chevalley-Maurel, H. J. Kroeze, S. Bezemer, C. de Korne, R. Withers, N. Raytselis, A. F. El Hebieshy, R. Q. Kim, M. Child, S. Kakuta, , C. J. Janse

This study shows that Plasmodium sporozoites use glutaminyl cyclase to modify surface proteins, evading mosquito immune detection and melanization.

bioRxiv · Jul 23, 2021Microbiology

Dual site-specific chemoenzymatic antibody fragment conjugation using CRISPR-based hybridoma engineering

C. M. Le Gall, J. M. van der Schoot, I. Ramos-Tomillero, M. Parlak Khalily, F. J. van Dalen, Z. Wijfjes, L. Smeding, D. van Dalen, A. Cammarata, K. M. Bonger, C. G. Figdor, F. A. Scheeren, M. Verdoes

This paper introduces a CRISPR-based method to engineer hybridoma cells that secrete dual-tagged Fab fragments, enabling site-specific conjugation of multiple cargos.

bioRxiv · Dec 8, 2020Biochemistry

Functional diversification of hybridoma produced antibodies by CRISPR/HDR genomic engineering

J. M. S. van der Schoot, F. L. Fennemann, M. Valente, Y. Dolen, I. M. Hagemans, A. M. D. Becker, C. M. Le Gall, D. van Dalen, A. Cevirgel, J. A. C. van Bruggen, M. Engelfriet, M. F. Fransen, T. Caval, A. E. H. Bentlage, M. Nederend, , F. A. Scheeren

This study presents a CRISPR/HDR platform to engineer hybridoma antibodies for diverse isotypes, formats, and species, enabling functional antibody diversification.

bioRxiv · Feb 15, 2019Bioengineering