Dynamic regulation of hierarchical heterogeneity in Acute Myeloid Leukemia serves as a tumor immunoevasion mechanism
C. Pospori, W. Grey, S. Gonzalez-Anton, S. V. Gibson, C. Georgiou, F. Birch, G. Stevens, T. Williams, R. Khorshed, M. L. R. Haltalli, M.-N. Skoufou-Papoutsaki, K. Sloan, H. H. Encabo, J. Hopkins, C. Christodoulidou, , C. L. Lo Celso
The paper shows that hierarchical heterogeneity in AML cells, regulated by immune responses, contributes to disease progression through PDL1 upregulation and dynamic balance between proliferation and immunosuppression.
bioRxiv · Dec 21, 2020 · PreprintCancer Biology