J. Hopkins

The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.

The paper investigates how OPTN reduces HSV-1-induced HSK severity and demyelination by suppressing IL-17 and hyperinflammatory T-cell responses in a mouse model.

The paper shows that hierarchical heterogeneity in AML cells, regulated by immune responses, contributes to disease progression through PDL1 upregulation and dynamic balance between proliferation and immunosuppression.

This study shows that HPSE disrupts innate defense responses, promoting cell survival during HSV-1 infection by inhibiting cell-intrinsic defenses and facilitating host cell reprogramming.

This study reports the spread of chloramphenicol-resistant Neisseria meningitidis across Southeast Asia using whole-genome sequencing of isolates from Cambodia, Thailand, and Laos.

This study identifies heparanase and cathepsin L as host enzymes that facilitate HSV-2 release from cells through heparan sulfate shedding and transcriptional regulation.