T. Williams

High-content high-resolution microscopy and deep learning assisted analysis reveals host and bacterial heterogeneity during Shigella infection

The paper uses high-resolution microscopy and deep learning to analyze host and bacterial heterogeneity during Shigella infection, revealing SEPT7 recruitment patterns linked to T3SS activation.

A genuinely hybrid, multiscale 3D cancer invasion and metastasis modelling framework

The paper enhances a hybrid multiscale cancer invasion model to better reflect biological dynamics and introduces a multi-organ metastasis framework.

Heterogeneity in lung macrophage control of Mycobacterium tuberculosis is determined by T cells

This study shows that T cell responses differentially affect M. tuberculosis control in alveolar macrophages versus monocyte-derived macrophages, influencing infection outcomes.

Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma

This study identifies the base excision repair pathway as a regulator of transcription-replication conflicts in pancreatic ductal adenocarcinoma, showing that its inhibition enhances DNA damage and reduces cell proliferation.

Sequence characterization of T, Bip, and Phbw demonstrates the role of MYB-bHLH-WD40 complexes and temperature in common bean seed color pattern formation

This study identifies mutations in MYB-bHLH-WD40 complex genes and shows temperature affects seed color patterns in common bean.

Choice of spatial discretisation influences the progression of viral infection within multicellular tissues

This study shows that spatial discretisation choices in viral dynamics models affect model outputs, especially when diffusion rates are low.

Metagenomics untangles metabolic adaptations of Antarctic endolithic 1 bacteria at the fringe of habitability

The paper analyzes metagenomic data from Antarctic endolithic microbiomes to identify metabolic strategies supporting life at extreme environmental limits.

Diving efficiency at depth and pre-breeding foraging effort increase with haemoglobin levels in gentoo penguins

This study finds that higher haemoglobin levels in gentoo penguins are linked to greater diving efficiency at depth and increased pre-breeding foraging effort, with implications for breeding behavior and conservation.

Morphogen-driven human iPSCs differentiation in 3D in vitro models of gastrulation is precluded by physical confinement.

This study shows that physical confinement reduces SOX17 expression in hiPSCs spheroids during gastrulation, but time-softening hydrogels rescue this effect.

Structure of the Commander endosomal trafficking complex linked to X-linked intellectual disability/Ritscher-Schinzel syndrome

The paper presents the structural model of the Commander endosomal trafficking complex, identifies disease-causing mutations, and reveals its molecular function in trafficking.

Inflammation durably imprints memory CD4+ T cells

This study compares transcriptional and epigenetic differences in Spike-specific CD4+ T cell memory between individuals primed by SARS-CoV-2 infection versus mRNA vaccination.

Towards optimised extracellular vesicle proteomics from cerebrospinal fluid

This study validates an UF-SEC method for isolating EVs from canine CSF and shows that proteomic analysis can be performed from as little as 0.5ml of CSF.

Host genetic background is a barrier to broadly effective vaccine protection: Relevance to BCG and Mycobacterium tuberculosis Infection

This study shows that host genetic background affects BCG vaccine efficacy against tuberculosis, with diverse immune responses in genetically varied mice.

Dynamic regulation of hierarchical heterogeneity in Acute Myeloid Leukemia serves as a tumor immunoevasion mechanism

The paper shows that hierarchical heterogeneity in AML cells, regulated by immune responses, contributes to disease progression through PDL1 upregulation and dynamic balance between proliferation and immunosuppression.

A workflow for visualizing human cancer biopsies using large-format electron microscopy

This paper describes a workflow for 2D and 3D imaging of human cancer biopsies using electron microscopy to reveal ultrastructural details not visible with conventional 2D EM.

The physiological regulation of macropinocytosis during Dictyostelium growth and development

The paper develops a flow cytometry assay to study macropinocytosis in Dictyostelium, showing it is upregulated by nutrients and downregulated by bacteria and starvation.