S. Durand

Complex sporulation-specific expression of transcription termination factor Rho highlights its involvement in Bacillus subtilis cell differentiation

This study identifies two distinct mechanisms for rho gene expression during Bacillus subtilis sporulation, showing Rho's role in spore formation and viability.

Temporal stability of sex ratio distorter prevalence in natural populations of the isopod Armadillidium vulgare

The paper examines the temporal stability of sex ratio distorter prevalence in Armadillidium vulgare populations over 12 years, finding little temporal variability and evidence of equilibria in SRD dynamics.

Small RNA regulation of an essential process induces bacterial resistance to aminoglycosides during oxidative stress

The paper shows that small RNAs FnrS and OxyS regulate iscR expression in E. coli, affecting Fe-S cluster synthesis and aminoglycoside resistance during oxidative stress.

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

This study shows that IRE1 regulates collagen secretion via P4HB, contributing to liver fibrosis in models of CCl4 and high fat diet.

New RoxS sRNA targets identified in B. subtilis by pulsed SILAC

This study identifies new RoxS sRNA targets in B. subtilis using pulsed SILAC, confirming known targets and expanding the list of TCA cycle enzymes regulated primarily at the translational level.

ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions

This study identifies ZEB1 as a key transcriptional regulator driving melanoma cell state transitions by modulating lineage-specific programs.

Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer.

This study shows GCN2 regulates 47S rRNA synthesis in colon cancer cells under different nutrient conditions, affecting cell survival and response to chemotherapy.

Heterogeneous distribution of sex ratio distorters in natural populations of the isopod Armadillidium vulgare

The paper investigates the distribution and dynamics of sex ratio distorters in Armadillidium vulgare, finding mutual exclusion between Wolbachia and the f element and suggesting a single integration event for the f element.

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation

The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

This study shows that a single cycle of transient OSKM expression reverses aging-related DNA methylation, transcriptional, and metabolic changes in multiple tissues of aged mice.

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

Induction of transposable element expression is central to innate sensing

The paper shows that exogenous PAMPs epigenetically activate LINE1 TEs, which engage cGAS to enhance innate immune responses.

Radiotherapy induces specific miRNA expression profiles in glioblastoma exosomes

The paper identifies miRNA expression changes in glioblastoma cells and their exosomes after radiotherapy, finding distinct miRNA signatures in exosomes that may serve as a biomarker for radiotherapy response.

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity

This study shows that neuroblastoma cells can switch between noradrenergic and mesenchymal identities through epigenetic reprogramming, influenced by both intrinsic factors and the microenvironment.

Novel regulation from novel interactions: Identification of an RNA sponge that controls the levels, processing and efficacy of the RoxS riboregulator of central metabolism in Bacillus subtilis

The paper identifies RosA, a sponge RNA in Bacillus subtilis, which regulates RoxS and FsrA sRNAs, linking carbon metabolism regulators to post-transcriptional control.

Transcriptional programs define intratumoral heterogeneity of Ewing sarcoma at single cell resolution

This study identifies transcriptional programs driving intratumoral heterogeneity in Ewing sarcoma using single-cell RNA-sequencing and chromatin analysis.