A. Nicolas

Soft extracellular matrix drives an endoplasmic reticulum stress-dependent S quiescence underlying molecular traits of pulmonary basal cells

The paper shows that soft extracellular matrix induces S-phase quiescence in progenitor cells via endoplasmic reticulum stress, aligning with molecular traits of pulmonary basal cells.

M2WISH: an easy and efficient protocol for whole-mount mRNA in situ hybridization that allows 3D cell resolution of gene expression in Arabidopsis thaliana.

The paper introduces M2WISH, a protocol for whole-mount mRNA in situ hybridization in Arabidopsis that enables 3D cellular resolution of gene expression during meristem conversion.

Targeting the cell and non-cell autonomous regulation of 47S synthesis by GCN2 in colon cancer.

This study shows GCN2 regulates 47S rRNA synthesis in colon cancer cells under different nutrient conditions, affecting cell survival and response to chemotherapy.

A third SARS-CoV-2 mRNA vaccine dose in people receiving hemodialysis overcomes B cell defects but elicits a skewed CD4+ T cell profile

A long interval between priming and boosting SARS-CoV-2 mRNA vaccine doses enhances B cell responses with limited impact on T cell immunity

This study shows that a longer interval between SARS-CoV-2 mRNA vaccine doses enhances B cell responses but has minimal impact on T cell immunity.

De novo stem cell establishment in meristems requires repression of organ boundary cell fate

The paper shows that DPA4 and SOD7 repress CUC genes to prevent ectopic boundary fate and enable proper axillary meristem establishment and stem cell niche formation.

Low centrosome numbers correlate with higher aggressivity in ovarian cancer

The paper analyzes centrosome numbers in ovarian cancers and finds that low centrosome numbers correlate with poor patient survival and mesenchymal subgroup enrichment.

Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

The paper examines B and T cell immunity responses to a 16-week interval BNT162b2 vaccine regimen, finding robust immune memory and functional associations between immune components.

Cancer/Testis genes are predictive of breast tumor subtypes

The paper identifies HORMAD1 and CT83 as Cancer/Testis genes predictive of basal-like breast tumors and shows their epigenetic regulation and prognostic significance.

PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer

This study identifies PRMT1 as a key regulator of EGFR and Wnt signaling in breast cancer and shows that targeting it with inhibitors can enhance chemotherapy and EGFR inhibitor efficacy in TNBC.

Tissue-resident FOLR2+ macrophages associate with tumor-infiltrating CD8+ T cells and with increased survival of breast cancer patients.

The paper identifies FOLR2+ macrophages in breast cancer that correlate with improved patient survival and co-localize with CD8+ T cells across multiple cancers.

Interactome analysis of C. elegans synapses by TurboID-based proximity labeling

The paper optimizes a TurboID proximity labeling protocol for C. elegans to characterize tissue and synaptic proteomes, identifying both known and novel proteins.

Cell-to-cell Mathematical Modeling of Arrhythmia Phenomena in the Heart

This study simulates arrhythmia phenomena in cardiac tissue using two cell topologies and identifies initial conditions that lead to fibrillation evolving into fluttering.

Unique Evolution of Antiviral Tetherin in Bats

This study characterizes the evolution of tetherin in bats, identifying unique structural variants and splice isoforms with antiviral functions.

Glial cell mechanosensitivity is reversed by adhesion cues

The paper shows that glial cells change their adhesion and proliferation preferences between stiff and soft substrates based on adhesive ligands, unlike neurons which follow rigidity gradients.

Priming of leaf litter decomposition by algae seems of minor importance in natural streams during autumn

The study assesses the role of algae in enhancing leaf litter decomposition in natural streams during autumn, finding a weak effect of algae on decomposition rates.