Hypoxia induces transcription of DOT1L in articular cartilage to protect against osteoarthritis
A. De Roover, A. Escribano, F. Cornelis, C. Cherifi, L. Casas-Fraile, A. Sermon, F. Cailotto, R. Lories, S. Monteagudo
This study identifies hypoxia-induced DOT1L transcription as a protective mechanism against osteoarthritis and shows that hypoxia mimetics can restore DOT1L function and slow disease progression.
bioRxiv · May 14, 2021Cell Biology