ANP32A represses Wnt signaling across tissues tissues thereby protecting against joint and heart disease
S. Monteagudo, F. Cornelis, X. Wang, A. De Roover, T. Peeters, J. Quintiens, A. Sermon, R. Coutinho de Almeida, I. Meulenbelt, R. Lories
This study identifies ANP32A as a repressor of Wnt signaling that protects against joint and heart disease by inhibiting Wnt target genes and oxidative stress.
bioRxiv · Apr 4, 2021Cell Biology