Structural and mutational analysis of the ribosome-arresting human XBP1u
V. Shanmuganathan, N. Schiller, A. Magoulopoulou, J. Cheng, K. Braunger, F. Cymer, O. Berninghausen, B. Beatrix, K. Kohno, G. v. Heijne, R. Beckmann
This study presents a cryo-EM structure of XBP1u and shows that only specific mutations in its AP region are optimal for translational arrest.
bioRxiv · Mar 25, 2019Biochemistry