K. Kohno

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α

This study shows that deleting XBP1 in hepatocytes causes liver injury in mice, which is due to excessive IRE1 activation rather than XBP1 loss itself.

Structural and mutational analysis of the ribosome-arresting human XBP1u

This study presents a cryo-EM structure of XBP1u and shows that only specific mutations in its AP region are optimal for translational arrest.