J. Cheng

Blm10 scaffolds 14-3-3 adaptors to the proteasome, and maintains cellular proteostatic balance and gamete quality

This study identifies Blm10 as a proteasome-associated protein that modulates proteasome activity and maintains proteostasis and gamete quality in yeast.

Super-Enhancer Driven ZFP36L1 Promotes PD-L1 Expression in Infiltrative Gastric Cancer

This study identifies ZFP36L1, driven by a super-enhancer, as a key regulator of PD-L1 expression in infiltrative gastric cancer, contributing to immune escape.

Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity

This study identifies a noncanonical function of ZMYND11 as an arginine-methylated HNRNPA1 reader that suppresses stress granule formation and tumor progression.

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

Multi-omics analyses and machine learning prediction of oviductal responses in the presence of gametes and embryos

The paper uses multi-omics data and machine learning to analyze oviductal responses to gametes and embryos in mice, identifying region-specific transcriptional and proteomic changes.

Structural and Biophysical Dynamics of Fungal Plasma Membrane Proteins and Implications for Echinocandin Action in Candida glabrata

This study investigates the structural and dynamic organization of plasma membrane proteins in Candida glabrata using cryo-ET and live cell imaging, revealing how echinocandin drugs affect their distribution and function.

Phosphodiesterase 1A physically interacts with YTHDF2 and reinforces the progression of non-small cell lung cancer

This study identifies PDE1A as a promoter of NSCLC metastasis through interaction with YTHDF2 and activation of the STAT3 pathway.

Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

Hexose transporters CsHT3/16 involved in post-phloem transport and affected cucumber fruit development

The paper identifies CsHT3/16 as key hexose transporters in cucumber fruit development, showing their role in sugar homeostasis and fruit size regulation through expression patterns and mutant analysis.

Hop stunt viroid infection alters host heterochromatin

This study investigates how HSVd viroid infection affects heterochromatin in Cucumis sativus by analyzing changes in H3K9me2 and H3K27me3 epigenetic marks and their transcriptional targets.

Swi4-dependent SWI4 transcription couples cell size to cell cycle commitment

This study shows that Swi4-dependent transcription couples cell size to cell cycle commitment in budding yeast by regulating Swi4 accumulation and Start timing.

Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.

This study identifies evolutionarily new genes in humans with disease phenotypes, showing their enrichment in male reproductive diseases and adaptive traits like brain size and color vision.

A Novel Tiled-Amplicon Sequencing Assay Targeting the Tomato Brown Rugose Fruit Virus (ToBRFV) Genome Reveals Widespread Distribution in Municipal Wastewater Treatment Systems in the Province of Ontario, Canada

The paper develops a tiled-amplicon sequencing assay to detect and track ToBRFV in municipal wastewater, revealing its widespread distribution in Ontario, Canada.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Heterochromatin re-organization associated with the transcriptional reprogramming under viral infection in Arabidopsis

This study identifies epigenetic reorganization during viral infection in Arabidopsis, linking it to transcriptional reprogramming and genome stability.

PQS and pyochelin in Pseudomonas aeruginosa share inner membrane transporters to mediate iron uptake

This study identifies shared inner membrane transporters for PQS-Fe3+ and PCH-Fe3+ in P. aeruginosa and shows their role in iron uptake and virulence.

Prevotella copri-related effects of a therapeutic food for malnutrition

The paper investigates the role of Prevotella copri in mediating the metabolic effects of a therapeutic food for malnutrition using gnotobiotic mouse models and multi-omics analyses.

Predicting Protein-Ligand Binding Structure Using E(n) Equivariant Graph Neural Networks

The paper introduces an E(n) Equivariant Graph Neural Network to predict ligand-protein binding structures, showing promising results for drug design.

Bacterial pathogens deliver water/solute-permeable channels as a virulence strategy

This study identifies AvrE/DspE-family effectors as water/solute-permeable channels that facilitate bacterial virulence by causing host cell swelling and death.

Snapshots of ribosome dynamics near atomic-resolution in situ: full insight into the eukaryotic elongation cycle

The paper uses cryo-EM to analyze ribosome conformations in yeast, revealing dynamics of the eukaryotic elongation cycle with elongation factors.

Crosstalk between the plasma membrane and cell-cell adhesion maintains epithelial identity for correct polarised cell divisions

This study shows that plasma membrane and cell-cell adhesion interactions are essential for correct polarized cell divisions in mammalian epithelial cells, with S100A11 playing a key regulatory role.

SUMOylation of PTEN promotes DNA end resection through directly dephosphorylating 53BP1 in homologous recombination repair

This study shows SUMOylation of PTEN enhances HR repair by dephosphorylating 53BP1, promoting DNA end resection and inhibiting NHEJ.

Rosuvastatin-Eluting Gold Nanoparticle-Loaded Perivascular Implantable Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model

This study evaluates AuNP- and rosuvastatin-loaded perivascular wraps for reducing neointimal hyperplasia and improving AVF maturation in a chronic kidney disease rat model.

Gold Nanoparticles for Monitoring of Mesenchymal Stem Cell-Loaded Bioresorbable Polymeric Wraps for Arteriovenous Fistulas

This study infuses gold nanoparticles into mesenchymal stem cell-seeded polymeric wraps to improve radiopacity for in vivo monitoring without affecting their beneficial effects on arteriovenous fistula maturation.

The vacuolar sugar transporter EARLY RESPONSE TO DEHYDRATION 6-LIKE4 regulates fructose signaling and plant growth

The paper shows that ERDL4 regulates fructose homeostasis, affecting plant growth and cold tolerance in Arabidopsis.

Bioresorbable mesenchymal stem cell-loaded electrospun polymeric scaffold inhibits neointimal hyperplasia following arteriovenous fistula formation in a rat model of chronic kidney disease

This study shows that a mesenchymal stem cell-loaded electrospun scaffold reduces neointimal hyperplasia in a rat CKD model by improving AVF maturation and reducing inflammation.