Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance
F. Lamballe, F. Ahmad, Y. Vinik, O. Castellanet, F. Daian, A. Mueller, U. Koehler, A.-L. Bailly, E. Josselin, R. Castellano, C. Cayrou, E. Charafe-Jauffret, G. B. Mills, V. Geli, J.-P. Borg, , F. Maina
This study develops a mouse model of TNBC that recapitulates human tumor heterogeneity and identifies a synergistic combination of WEE1 and BCL-XL inhibition as a potential treatment.
bioRxiv · Jun 22, 2020Cancer Biology