Intra-Host Mutation Rate of Acute SARS-CoV-2 Infection During the Initial Pandemic Wave
K. El Haddad, T. M. Adhikari, T. Zheng, Y.-W. Cheng, X. Leng, X. Zhang, D. Rhoads, J. Ko, S. Worley, J. Li, B. Rubin, F. Esper
This study quantifies the intra-host mutation rate of SARS-CoV-2 during acute infection and finds higher mutation rates in viruses with NSP-14 mutations and in immunocompromised patients.
bioRxiv · Mar 24, 2023Evolutionary Biology