J. Ko

Optimizing Cell Therapy by Sorting Cells with High Extracellular Vesicle Secretion

The paper develops a method to enrich cells with high extracellular vesicle secretion and shows improved therapeutic outcomes in a mouse model.

Intra-Host Mutation Rate of Acute SARS-CoV-2 Infection During the Initial Pandemic Wave

This study quantifies the intra-host mutation rate of SARS-CoV-2 during acute infection and finds higher mutation rates in viruses with NSP-14 mutations and in immunocompromised patients.

Zika virus infection induces IL-1β-mediated inflammatory responses by macrophages in the brain of an adult mouse model

This study investigates ZIKV-induced neuroinflammation in adult mice, finding that macrophage IL-1β expression and complement activation contribute to neuroinflammatory damage.

SARS-CoV-2 Infection of Microglia Elicits Pro-inflammatory Activation and Apoptotic Cell Death

This paper shows SARS-CoV-2 directly infects human microglia, causing pro-inflammatory activation and apoptosis, which may contribute to neurological issues in COVID-19 patients.

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment

This study shows FGFR1 is critical for prostate cancer stem cell proliferation and that FGFR inhibitors may be effective for AR-independent CRPC.

Protective Effects of STI-2020 Antibody Delivered Post-Infection by the Intranasal or Intravenous Route in a Syrian Golden Hamster COVID-19 Model

This study evaluates the efficacy of STI-2020 antibody delivered post-infection via intranasal or intravenous routes in a hamster model of COVID-19, showing reduced disease severity and duration.

Calcium-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells

This study identifies DHHC21 as a calcium/calmodulin-dependent enzyme critical for CD4+ T cell activation and differentiation through S-acylation of signaling proteins.

Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ

This study determines the structural basis of SALM3 dimerization and its interaction with PTPσ, showing that dimerization is required for synaptogenic activity.

Proteomic and Biological Profiling of Extracellular Vesicles from Alzheimer’s Disease Human Brain Tissues

The paper profiles proteomic and biological features of extracellular vesicles from Alzheimer’s disease and control brain tissues, identifying new signature proteins associated with AD.