Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14
L. Peri, D. Matzov, D. R. Huxley, A. Rainish, F. Fierro, L. Sapir, T. Pfeiffer, L. Waterloo, H. Huebner, D. Weikert, Y. Peleg, P. Gmeiner, P. Mccormick, M. Y. Niv, M. Shalev-Benami
The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.
bioRxiv · Apr 10, 2024Biochemistry