Author

D. Weikert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

P. Gmeiner· 2 shared A. A. Inoue· 1 shared A. Allikalt· 1 shared A. Basbaum· 1 shared A. Rainish· 1 shared A. Ullrich· 1 shared B. Bottcher· 1 shared B. K. Shoichet· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

P. Gmeiner

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14

L. Peri, D. Matzov, D. R. Huxley, A. Rainish, F. Fierro, L. Sapir, T. Pfeiffer, L. Waterloo, H. Huebner, D. Weikert, Y. Peleg, P. Gmeiner, P. Mccormick, M. Y. Niv, M. Shalev-Benami

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

bioRxiv · Apr 10, 2024Biochemistry

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

A. Ullrich, J. Schneider, J. M. Braz, E. Neu, N. Staffen, M. Stanek, J. Blahova, T. Hove, T. Albert, A. Allikalt, S. Lober, K. Bhardwaj, S. Rodriguez-Rosado, E. A. Fink, T. Rasmussen, , P. Gmeiner

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

bioRxiv · Sep 11, 2023 · PreprintPharmacology & Toxicology