Author

H. Huebner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

P. Gmeiner· 2 shared A. Rainish· 1 shared B. Kobilka· 1 shared D. Matzov· 1 shared D. R. Huxley· 1 shared D. Weikert· 1 shared F. Fierro· 1 shared F. Hetzer· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

P. Gmeiner

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Author profile →

2 papers

Recent·Most cited

Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14

L. Peri, D. Matzov, D. R. Huxley, A. Rainish, F. Fierro, L. Sapir, T. Pfeiffer, L. Waterloo, H. Huebner, D. Weikert, Y. Peleg, P. Gmeiner, P. Mccormick, M. Y. Niv, M. Shalev-Benami

The paper reveals the cryo-EM structure of hTAS2R14 bound to FFA and gustducin, showing dual binding pockets and supporting a dual binding mode for FFA.

bioRxiv · Apr 10, 2024Biochemistry

Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists

H. Wang, F. Hetzer, W. Huang, Q. Qu, J. Meyerowitz, J. Kaindl, H. Huebner, G. Skiniotis, B. Kobilka, P. Gmeiner

The paper reports cryoEM structures of the μ-opioid receptor bound to biased agonists PZM21 and FH210, revealing structural basis for reduced β-arrestin recruitment and guiding development of safer analgesics.

bioRxiv · Mar 22, 2022Pharmacology & Toxicology