Author

Y. Peleg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Microbiology· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Organism:E. coli· 1

Frequent Co-Authors

A. Tirosh· 2 shared E. Yifrach· 2 shared E. Zalckvar· 2 shared M. Eisenstein· 2 shared M. Schuldiner· 2 shared S. Albeck· 2 shared A. Brandis· 1 shared A. Fadel· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

A. Tirosh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Complex biophysical changes and reduced neuronal firing in an SCN8A variant associated with developmental delay and epilepsy

S. Quinn, N. Zhang, T. A. Fenton, M. Brusel, P. Muruganandam, Y. Peleg, M. Giladi, Y. Haitin, H. Lerche, H. Bassan, Y. Liu, R. Ben-Shalom, M. Rubinstein

This study characterizes the biophysical and neurophysiological effects of the SCN8A p.(Gly1625Arg) mutation, showing a complex mix of gain-and loss-of-function properties leading to reduced neuronal firing.

bioRxiv · Dec 4, 2023 · PreprintPhysiology

Determining the targeting specificity of the selective peroxisomal targeting factor Pex9

E. Yifrach, M. Ruowitz, L. D. Cruz Zaragoza, A. Tirosh, Z. Gazi, Y. Peleg, M. Kunze, M. Eisenstein, W. Schliebs, M. Schuldiner, R. Erdmann, E. Zalckvar

The paper investigates the targeting specificity of Pex9 by analyzing PTS1 motifs and structural features, finding that hydrophobicity of the amino acid before the PTS1 tripeptide determines its binding specificity.

bioRxiv · Feb 2, 2022Cell Biology

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

E. Yifrach, D. Holbrook-Smith, J. Burgi, A. Othman, M. Eisenstein, C. W. T. Van Roermund, W. Visser, A. Tirosh, C. Bibi, S. Galor, U. Weil, A. Fadel, Y. Peleg, H. Waterham, R. J. Wanders, , E. Zalckvar

The paper identifies new peroxisomal functions in yeast by expanding the organellar proteome and analyzing sub-organellar localization and metabolic roles.

bioRxiv · Dec 8, 2021Cell Biology

Bringing BOS to light: Uncovering the key enzyme in the biosynthesis of the neurotoxin β-ODAP in Grass Pea (Lathyrus sativus L.)

M. Goldsmith, S. Barad, M. Knafo, A. Savidor, S. Ben-Dor, A. Brandis, T. Mehlman, Y. Peleg, S. Albeck, O. Dym, E. Benzeev, Z. Reich

The paper identifies the enzyme BOS responsible for β-ODAP biosynthesis in grass pea, revealing its structure and function after over 50 years of research.

bioRxiv · Nov 29, 2020 · PreprintPlant Biology

Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

M. Heyne, J. Shirian, I. Cohen, Y. Peleg, E. S. Radisky, N. Papo, J. M. Shifman

This study quantifies mutational effects on binding affinity in three homologous protease-inhibitor complexes, revealing distinct binding landscapes and epistasis patterns.

bioRxiv · Oct 14, 2020Biophysics

Expression of a recombinant, 4’-Phosphopantetheinylated, active M. tuberculosis Fatty acid Synthase I in E. coli

S. Baron, Y. Peleg, J. Grunwald, D. Morgenstern, N. Elad, M. Peretz, S. Albeck, Y. Levin, J. T. Welch, K. A. Deweerd, A. Schwartz, Y. Burstein, R. Diskin, Z. Shakked, O. Zimhony

This paper describes the expression and activation of Mtb FAS I in E. coli using AcpS, confirming its biochemical activity and structural properties.

bioRxiv · Aug 28, 2018Microbiology