Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
E. Bagnoli, Y.-E. Lin, S. Burel, E. Jaimon, O. Antico, C. Themistokleous, J. Nikoloff, I. Morella, J. Watzlawik, F. Fiesel, W. Springer, F. Tonelli, S. Brooks, S. Dunnett, R. Brambilla, , M. Muqit
This study shows LRRK2 and PINK1 function in parallel neuroprotective pathways affecting ciliogenesis in Parkinson's disease, suggesting shared therapeutic targets.
bioRxiv · Jun 11, 2024Biochemistry