Author

W. Springer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Watzlawik· 2 shared A. Covallero· 1 shared A. Raybuck· 1 shared A. Sickmann· 1 shared B. Rieger· 1 shared C. Muench· 1 shared C. Showkat· 1 shared C. Themistokleous· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

J. Watzlawik

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Author profile →

4 papers

Recent·Most cited

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain

E. Bagnoli, Y.-E. Lin, S. Burel, E. Jaimon, O. Antico, C. Themistokleous, J. Nikoloff, I. Morella, J. Watzlawik, F. Fiesel, W. Springer, F. Tonelli, S. Brooks, S. Dunnett, R. Brambilla, , M. Muqit

This study shows LRRK2 and PINK1 function in parallel neuroprotective pathways affecting ciliogenesis in Parkinson's disease, suggesting shared therapeutic targets.

bioRxiv · Jun 11, 2024Biochemistry

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

H. Zeng, X. Zhu, Y. Wu, Y. Li, X. Zhou, J. Watzlawik, Y. M. Chen, A. Raybuck, D. Billadeau, V. Shapiro, W. Springer, J. Sun, M. R. Boothby

This study shows that Rag-GTPases regulate B cell metabolism and immunity by restraining TFEB/TFE3 to maintain mitochondrial fitness and support T-independent humoral immunity.

bioRxiv · Feb 26, 2024Immunology

LUBAC assembles a signaling platform at mitochondria for signal amplification and shuttling of NF-ĸB to the nucleus

Z. Wu, L. A. Berlemann, V. Bader, D. A. Sehr, E. Eilers, A. Covallero, J. Meschede, L. Angersbach, C. Showkat, J. B. Michaelis, C. Muench, B. Rieger, D. Namgaladze, M. G. Herrera, F. C. Fiesel, , K. F. Winklhofer

This study shows that LUBAC assembles at mitochondria to amplify and shuttle NF-κB signals to the nucleus during TNF activation.

bioRxiv · May 27, 2022 · PreprintCell Biology

Structure-based design and characterization of Parkin activating mutations

J.-F. Trempe, M. U. Stevens, N. Croteau, M. A. Eldeeb, Z. W. Zeng, R. Toth, T. M. Durcan, W. Springer, E. A. Fon, M. M. K. Muqit

The paper identifies three Parkin activating mutations that rescue mitophagy defects in cell-based studies, suggesting therapeutic potential for Parkinson's disease.

bioRxiv · Feb 22, 2022Biochemistry