Jagged1 overexpression on T cells induces thymic regulatory T cells leading to thymic involution
J. Kritikou, I. Sanchez-Pascual, J. P. Munoz-Miranda, N. Vashist, A. K. Wagner, X. M. Zhang, E. Assarsson, M. Dominguez-Villar, H. Yagita, F. Garcia-Cozar, P. Riese, R. A. Harris, H.-G. Ljunggrean, B. Chambers
This study identifies Jagged1 overexpression in T cells as a driver of thymic involution through increased regulatory T cells, observed in a mouse model with thymic atrophy.
bioRxiv · Aug 25, 2022 · PreprintImmunology