P. Riese

Jagged1 overexpression on T cells induces thymic regulatory T cells leading to thymic involution

This study identifies Jagged1 overexpression in T cells as a driver of thymic involution through increased regulatory T cells, observed in a mouse model with thymic atrophy.

PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency

The paper investigates PD-1 expression on NK cells, showing its association with tumor-infiltrating NK cells and altered phenotypes in PD-1-deficient mice.

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations

The paper describes the selection of a SARS-CoV-2 neutralizing antibody from COVID-19 patients using phage display, showing it binds the ACE2-RBD interface and remains effective against emerging RBD mutations.

MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

The paper identifies a human-derived monoclonal antibody, MTX-COVAB, with potent neutralizing activity against SARS-CoV-2 in vitro and in a hamster model, showing efficacy against variants and readiness for clinical testing.

SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface

The paper identifies potent SARS-CoV-2 neutralizing antibodies from pre-pandemic human donors that bind the RBD-ACE2 interface, showing high neutralization efficacy in vitro.