Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment
M. Villa, D. E. Sanin, P. Apostolova, M. Corrado, A. M. Kabat, C. Cristinzio, A. Regina, G. Carrizo, N. Rana, M. A. Stanczak, F. Baixauli, K. M. Grzes, J. Cupovic, F. Solagna, A. Hackl, , E. L. Pearce
This study identifies a PGE2-autophagy-glutathione axis that enables CD8+ T cells to adapt metabolically to the intestinal microenvironment.
bioRxiv · Mar 13, 2023 · PreprintImmunology