E. L. Pearce

Prostaglandin E2 controls the metabolic adaptation of T cells to the intestinal microenvironment

This study identifies a PGE2-autophagy-glutathione axis that enables CD8+ T cells to adapt metabolically to the intestinal microenvironment.

HIGHLY PHAGOCYTIC LIPID-ASSOCIATED MACROPHAGES (LAMs) ARE INCREASED IN COLONIC LAMINA PROPRIA IN OBESITY

The paper identifies obesity-induced lipid-associated macrophages (LAMs) in the colonic lamina propria, showing increased phagocytic activity and metabolic changes.

mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity

This study identifies mTOR as a host factor that protects macrophages from Mycobacterium-induced death by regulating mitochondrial metabolism.

In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

This study shows that fatty acid oxidation in macrophages supports alternative activation by maintaining glutamate levels, and that glutamine metabolism compensates for FAO disruption.

Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection

The paper shows that Th2 lymphocytes in mesenteric adipose tissue interact with stromal cells to influence adiposity during helminth infection.

Predictive framework of macrophage activation

The paper establishes a common framework for macrophage activation by identifying conserved transcriptional profiles across tissues and conditions.

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

This study shows that targeting cancer glycosylation with an antibody-sialidase conjugate repolarizes tumor-associated macrophages and enhances immune checkpoint blockade efficacy in mouse models.

Triacylglycerol synthesis enhances macrophage inflammatory function

This study shows that triacylglycerol synthesis in macrophages is essential for inflammatory function, as inhibiting it reduces proinflammatory cytokines and phagocytic capacity.

Polyamine Metabolism Regulates the T Cell Epigenome Through Hypusination

This study shows that polyamine metabolism, specifically through hypusination, is essential for maintaining T cell subset identity by regulating the epigenome and transcriptional programs.