A. Castoldi

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice

This study shows that PAHSAs improve insulin sensitivity in diet-induced obese mice via the gut microbiota, with sex-specific effects observed.

Lack of mTORC2 signaling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis

This study shows that blocking mTORC2 in CD11c+ myeloid cells reduces colitis by impairing DC migration and Th17 cell infiltration.

HIGHLY PHAGOCYTIC LIPID-ASSOCIATED MACROPHAGES (LAMs) ARE INCREASED IN COLONIC LAMINA PROPRIA IN OBESITY

The paper identifies obesity-induced lipid-associated macrophages (LAMs) in the colonic lamina propria, showing increased phagocytic activity and metabolic changes.

In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

This study shows that fatty acid oxidation in macrophages supports alternative activation by maintaining glutamate levels, and that glutamine metabolism compensates for FAO disruption.

Resident T cells orchestrate adipose tissue remodeling in a site peripheral to infection

The paper shows that Th2 lymphocytes in mesenteric adipose tissue interact with stromal cells to influence adiposity during helminth infection.

Predictive framework of macrophage activation

The paper establishes a common framework for macrophage activation by identifying conserved transcriptional profiles across tissues and conditions.

Triacylglycerol synthesis enhances macrophage inflammatory function

This study shows that triacylglycerol synthesis in macrophages is essential for inflammatory function, as inhibiting it reduces proinflammatory cytokines and phagocytic capacity.