A. Patterson

Maternal diet alters offspring early life host-microbiota communication through goblet cells, resulting in long-lasting diseases susceptibility

This study shows maternal diet affects offspring microbiota and health through goblet cells, leading to long-term disease susceptibility.

Fine-scale movement data reveal surface foraging and nocturnal flight activity in the endangered Bermuda petrel

This study uses fine-scale movement data from Bermuda petrels to reveal surface foraging and nocturnal flight behaviors, providing insights into their foraging strategies and activity patterns.

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a New Mexico desert oasis: multiple pathways for wildlife and human exposure

This study measures high levels of PFAS in vertebrates at a New Mexico desert oasis, showing contamination across multiple trophic levels and exposure pathways.

Comammox bacterial preference for urea influences its interactions with aerobic nitrifiers.

This study investigates how nitrogen source and loading conditions affect interactions between comammox bacteria and aerobic nitrifiers in continuous flow reactors, finding that urea promotes comammox abundance while ammonia inhibits it.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.

This study identifies key residues in eIF6 and RPL23 that mediate their interaction and shows how mutations in SDS disrupt this interaction, offering a therapeutic target for cancer and SDS.

In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

This study shows that fatty acid oxidation in macrophages supports alternative activation by maintaining glutamate levels, and that glutamine metabolism compensates for FAO disruption.

Rtt105 configurationally staples RPA and blocks facilitated exchange and interactions with RPA-interacting proteins

This study shows Rtt105 binds to RPA, staples it, and blocks RIP interactions without ssDNA, while stabilizing RPA-ssDNA filaments with ssDNA.

Hydrogen-deuterium exchange reveals a dynamic DNA binding map of Replication Protein A

This study uses HDX-MS to analyze the dynamic DNA binding properties of RPA domains, revealing that DBD-C is most involved in stabilizing RPA on ssDNA.