Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques
X. Yan, S. Ols, R. Arcoverde Cerveira, K. Lenart, F. Hellgren, K. Ye, A. Cagigi, M. Buggert, F. Nimmerjahn, J. Falkesgaard Hojen, D. Parera, U. Pessara, S. Fischer, K. Lore
This study introduces an Fcγ-receptor independent agonistic anti-CD40 antibody that activates immune cells in vitro and in vivo in rhesus macaques, showing potential as an immunostimulatory adjuvant.
bioRxiv · Mar 22, 2023Immunology