K. Ye

The main duct of von Ebner's glands is a source of Sox10+ taste bud progenitors and susceptible to pathogen infections

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

Evolutionary analysis of conserved non-coding elements subsequent to whole-genome duplication in opium poppy

This study analyzes the evolutionary patterns of regulatory and coding sequences in opium poppy following whole-genome duplication, showing rapid regulatory element evolution contributes to new phenotypes.

Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques

This study introduces an Fcγ-receptor independent agonistic anti-CD40 antibody that activates immune cells in vitro and in vivo in rhesus macaques, showing potential as an immunostimulatory adjuvant.

Pan-cancer in silico analysis of somatic mutations in G-protein coupled receptors: The effect of evolutionary conservation and natural variance

This study analyzes somatic mutations in GPCRs across cancer patients and healthy individuals, identifying conserved mutation hotspots and prioritizing GPCRs for further cancer research.

Infant antibody repertoires during the first two years of influenza vaccination

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

Intestinal stem cell aging at single-cell resolution: functional perturbations alter cell developmental trajectory reversed by gerotherapeutics

This study uses single-cell RNA sequencing to show that aging impairs intestinal stem cell maturation, which is reversed by metformin and rapamycin.

The tissue-specific chromatin accessibility landscape of Papaver somniferum

This study identifies tissue-specific chromatin accessibility and gene expression in Papaver somniferum to uncover regulatory mechanisms for morphine and noscapine accumulation.

Dynamic intestinal stem cell plasticity and lineage remodeling 1 by a nutritional environment relevant to human risk for tumorigenesis

This study shows that a nutrient-rich diet reprograms intestinal stem cells and lineages, promoting tumorigenesis by altering stem cell function and inducing chronic inflammation.

Molecular and structural mechanisms of ZZ domain-mediated cargo recognition by autophagy receptor Nbr1

The paper identifies two new NVT cargos bound by Nbr1-ZZ1 and reveals the structural basis of ZZ domain-mediated cargo recognition in selective autophagy.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

Cerebrospinal fluids from healthy pregnant women does not harbor a detectable microbial community

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

Cryo-EM structure of yeast 90S preribosome at 3.4 Angstrom resolution

The paper presents a 3.4 Angstrom cryo-EM structure of yeast 90S preribosome, revealing new insights into the conformation of the 18S rRNA central domain.

Proto-sex locus in large yellow croaker provides insights into early evolution of the sex chromosome

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

TMT-Based Quantitative Proteomic Analysis of Intestinal Organoids Infected by Listeria monocytogenes with Different Virulence

The paper uses TMT-based proteomics to compare host protein responses to virulent and low virulent Listeria monocytogenes strains in intestinal organoids, identifying differentially expressed proteins and their functional roles.

Network Inference from Multi-omic Data Uncovers Dynamic Transcriptional Regulation Modules in Pathogenic Fungus Fusarium graminearum

This paper infers dynamic transcriptional regulatory networks in Fusarium graminearum using multi-omic data and a Bayesian network algorithm, revealing condition-specific modules and their associations with phenotypes.

Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half assembled intermediate

The paper reports the cryo-EM structure of an early pre-60S ribosome intermediate, revealing a half-assembled subunit and key assembly factors involved in rRNA domain joining.