S. Fischer

Bacterial motility depends on a critical flagellum length and energy-optimised assembly

This study shows that bacterial flagellum assembly is optimized for energy efficiency and motility by balancing secretion rate and filament length.

mTOR controls growth and internal architecture of human breast cancer spheroids

This study investigates how mTOR signaling, through mTORC1 and mTORC2, influences the growth and internal architecture of human breast cancer spheroids.

Kinetochore and ionomic adaptation to whole genome duplication

This study identifies genetic adaptations to whole genome duplication in Cochlearia species, highlighting kinetochore and ion transport gene changes across multiple WGD events.

Does the stress axis mediate behavioural flexibility in a social cichlid, Neolamprologus pulcher?

This study investigates how blocking glucocorticoid receptors affects behavioural flexibility in Neolamprologus pulcher fish during predator exposure and detour tasks, finding impaired flexibility and increased fear-related behaviours.

Risk of urban Mayaro virus (Alphavirus: Togaviridae) transmission: is Aedes aegypti a competent vector?

This study assesses the competence of Aedes aegypti mosquitoes as vectors for Mayaro virus, finding they require higher viral doses than humans can produce to transmit the virus effectively.

Latitudinal scaling of aggregation with abundance and its consequences for coexistence in species rich forests

The paper examines latitudinal patterns in species aggregation and abundance, showing how these patterns affect coexistence in forests and introduces a framework to model their impact on extinction risk.

Cell targeting and immunostimulatory properties of a novel Fcγ-receptor independent agonistic anti-CD40 antibody in rhesus macaques

This study introduces an Fcγ-receptor independent agonistic anti-CD40 antibody that activates immune cells in vitro and in vivo in rhesus macaques, showing potential as an immunostimulatory adjuvant.

Fcgamma-receptor-independent controlled activation of CD40 canonical signaling by novel therpeutic antibodies for cancer therapy

Novel Fc-silenced anti-CD40 antibodies activate antigen-presenting cells and humanized mice without Fcγ-receptor dependence, showing efficacy and reduced toxicity compared to existing therapies.

Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells

The paper develops a peptide inhibitor targeting the Elongin BC dimer, showing reduced cancer cell viability and increased apoptosis by blocking its interaction partners.

The Influences of Stomatal Size and Density on Rice Drought, Salinity and VPD Resilience

The paper examines how stomatal size and density in rice affect resilience to drought, salinity, and VPD, finding that traditional varieties with high density and small size are more drought-resistant than those with low density and large size.

The kinase activity of the cancer stem cell marker DCLK1 drives gastric cancer progression by reprogramming the stromal tumor landscape

This study identifies DCLK1 kinase activity as a driver of gastric cancer progression by reprogramming the tumor stroma and promoting invasiveness and metastasis.

Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids

The paper identifies 91 differentially expressed genes in neo-tetraploid Arabidopsis roots associated with elevated leaf potassium, linking whole-genome duplication to K homeostasis.

Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity

This study uses scRNA-seq and snRNA-seq to analyze 73,295 human liver cells, revealing heterogeneity in hepatic stellate cells, cholangiocytes, and interzonal hepatocytes.

Shaping sustainable harvest boundaries for marine populations despite estimation bias

This paper develops a method to optimize harvest control rules for marine populations despite estimation bias, showing that accounting for biases can reduce overharvest risk and stabilize catch limits.

Convergence and novelty in adaptation to whole genome duplication in three independent polyploids

The paper investigates adaptation to whole genome duplication in three polyploid species, finding flexible gene recruitment and varying convergence in adaptive processes.

Light-driven formation of high-valent manganese oxide by photosystem II supports evolutionary role in early bioenergetics

The paper shows modern photosystem II can form birnessite-type Mn oxides, suggesting an evolutionary link between ancient Mn oxide production and current water oxidation mechanisms.

The molecular recognition of phosphatidic acid by an amphipathic helix in Opi1

This study identifies an amphipathic helix in Opi1 that selectively binds phosphatidic acid over phosphatidylserine, revealing lipid headgroup selectivity in membrane recognition.