Sanglifehrin A mitigates multi-organ fibrosis in vivo by inducing secretion of the collagen chaperone cyclophilin B
H. A. Flaxman, M.-A. Chrysovergi, H. Han, F. Kabir, R. T. Lister, C.-F. Chang, K. E. Black, D. Lagares, C. M. Woo
This study identifies cyclophilin B as the target of sanglifehrin A, showing it reduces collagen synthesis in fibrotic tissues by inducing cyclophilin B secretion.
bioRxiv · Mar 9, 2023 · PreprintBiochemistry