BiochemistrybioRxivPreprint
Sanglifehrin A mitigates multi-organ fibrosis in vivo by inducing secretion of the collagen chaperone cyclophilin B
H. A. Flaxman, M.-A. Chrysovergi, H. Han…·C. M. Woo
This study identifies cyclophilin B as the target of sanglifehrin A, showing it reduces collagen synthesis in fibrotic tissues by inducing cyclophilin B secretion.