Cancer BiologybioRxiv
A key role of the WEE1-CDK1 axis in mediating TKI-therapy resistance in FLT3-ITD positive acute myeloid leukemia patients
G. Massacci, V. Venafra, S. Latini…·F. Sacco
The paper identifies the WEE1-CDK1 axis as a key driver of TKI resistance in FLT3-ITD positive AML and suggests combination therapy as a potential treatment.
DOI 10.1038/s41375-022-01785-w