Destabilized 3UTR ARE therapeutically degrades ERBB2 in drug-resistant ERBB2+ cancer models
C. Awah, Y. Glemaud, F. Levine, K. Yang, A. Ansary, F. Dong, L. Ash, J. Zhang, D. Weiser, O. O. Ogunwobi
The paper develops a method to degrade ERBB2 mRNA and protein by destabilizing its 3UTR AU-rich elements, showing efficacy in drug-resistant cancer models.
bioRxiv · Aug 14, 2022 · PreprintCancer Biology