F. Dong

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid

This study identifies a signaling relay system involving maternal vGluT2 and embryonic mGluR3 that controls offspring wing dimorphism in pea aphids through transgenerational phenotypic plasticity.

Genetic purging of strongly deleterious mutations underlies black-necked crane's unusual escape from an extinction vortex

This study shows black-necked cranes rapidly recovered from a population bottleneck through genetic purging of deleterious mutations, escaping an extinction vortex.

Urine proteomic analysis of patients with schizophrenia

This study identifies 35 differential urinary proteins between unmedicated schizophrenia patients and healthy controls, with 15 linked to schizophrenia mechanisms, showing potential as diagnostic markers.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Contact toxicity, antifeedant activity and oviposition preference of osthole against agricultural pests

This study evaluates the contact toxicity, antifeedant activity, and oviposition preference of osthole against three agricultural pests to assess its potential for pest control.

A KDELR-mediated ER retrieval system guides the signaling pathways of UPR and AMPK to maintain cellular homeostasis

This study shows that the KDELR/Erd2-mediated ER retrieval system regulates UPR and AMPK signaling to maintain cellular homeostasis by affecting mitochondrial respiration and ROS levels.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

A novel purity analysis method of bovine milk-derived exosomes by two-dimensional high-performance liquid chromatography

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

Complex chemical signals dictate Ah receptor activation through the gut-lung axis

The paper shows that urolithin A enhances AHR activity in gut and lung tissues by reducing clearance via CYP1A1/1B1, suggesting a role for dietary substrates in modulating AHR signaling through the gut-lung axis.

Contribution of circulating host and microbial tryptophan metabolites towards Ah receptor activation

This study identifies host and microbial tryptophan metabolites in serum that activate the AHR, showing host production dominates in mice despite microbial sources.

Destabilized 3UTR ARE therapeutically degrades ERBB2 in drug-resistant ERBB2+ cancer models

The paper develops a method to degrade ERBB2 mRNA and protein by destabilizing its 3UTR AU-rich elements, showing efficacy in drug-resistant cancer models.

Hoxb5 reprograms murine multipotent blood progenitors into hematopoietic stem cell-like cells

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow

This study identifies early megakaryocyte lineage-committed progenitors in adult mouse bone marrow and proposes a differentiation model involving intermediate progenitors.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

Experimental Evolution of Pseudomonas putida under Silver Ion versus Nanoparticle Stress

This study evolves Pseudomonas putida under silver ion or nanoparticle stress, finding distinct mutation patterns linked to different cellular targets and suggesting nanoparticle-specific toxicity mechanisms.

Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

Klp2 and Ase1 synergize to maintain meiotic spindle stability during metaphase I

This study compares spindle dynamics in mitosis and meiosis I using fission yeast, showing Klp2 maintains meiotic spindle stability with Ase1, but not mitotic spindles.

The Histone Demethylase KDM4D Promotes Hepatic Fibrogenesis by Modulating Toll-Like Receptor 4 Signaling Pathway

This study identifies KDM4D as a key regulator of hepatic fibrosis by modulating TLR4 signaling through histone demethylation in HSCs.

Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection

This study investigates nasal immune responses in rainbow trout to Ichthyophthirius multifiliis infection, finding parasite-specific IgT production and B-cell proliferation in the nasal mucosa.