Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunity
S. R. Mosley, A. Chen, D. N. Doell, S. Choi, C. Mowat, F. Meier-Stephenson, V. Meier-Stephenson, K. Baker
The paper shows that genomic instability in MSI CRCs generates cytosolic DNA that enhances STING activation and anti-tumor immunity via dendritic cells, suggesting improved DNA-based therapies for CIN CRCs.
bioRxiv · Mar 8, 2024 · PreprintCancer Biology