K. Baker

Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality

The paper identifies synthetic dosage lethality targets for PLK1-overexpressing cancers using genome-wide screens and validates key hits to show their therapeutic potential.

Navigating the Night: Effects of Artificial Light on the Behaviour of Atlantic Puffin Fledglings

This study investigates how artificial light affects Atlantic Puffin fledglings' behavior, finding that illumination increases stranding and that light attraction is not mitigated by changing light types.

Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunity

The paper shows that genomic instability in MSI CRCs generates cytosolic DNA that enhances STING activation and anti-tumor immunity via dendritic cells, suggesting improved DNA-based therapies for CIN CRCs.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

cGAS/STING and NLRP3 cooperatively activate CD8+ T cell-mediated anti-tumor immunity in colorectal cancer

This study shows that cGAS/STING and NLRP3 pathways work together to enhance CD8+ T cell anti-tumor immunity in colorectal cancer, improving immunotherapy response.

A new strategy for identifying polysialylated proteins reveals they are secreted from cancer cells as soluble proteins and as part of extracellular vesicles

This study identifies polysialylated proteins secreted by MCF-7 cancer cells as soluble proteins and extracellular vesicles using a novel metabolic labeling method.

Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks

This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.

Identification of Fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration

This paper identifies fluoxetine as a potential repurposed drug for dry AMD by showing it inhibits NLRP3-ASC inflammasome activation and reduces RPE degeneration in mice, supported by epidemiological data.

Antitumor immunity in dMMR colorectal cancers requires interferon-induced CCL5 and CXCL10

This study identifies that dMMR CRCs recruit CD8+ T cells via CCL5 and CXCL10 overexpression driven by cGAS/STING and IFN signaling, offering a therapeutic target for improving immune response in other CRCs.

RLP/K enrichment sequencing; a novel method to identify receptor-like protein (RLP) and receptor-like kinase (RLK) genes

This paper introduces RLP/KSeq, a method to rapidly map receptor-like protein (RLP) and receptor-like kinase (RLK) genes in plants, demonstrating its application in identifying PRRs in Solanum species.

Maternal antibodies provide partial protection from postnatal Zika viremia in nonhuman primates

This study shows that maternal antibodies provide partial protection against postnatal Zika virus infection in infant nonhuman primates, reducing viremia but not completely preventing viral dissemination.

Horizontal gene transfer as an indispensible driver for Neocallimastigomycota evolution into a distinct gut-dwelling fungal lineage

This paper identifies 283 horizontal gene transfer events in anaerobic gut fungi, showing HGT's role in their adaptation to the herbivorous gut environment.

Enteric Pathogen Diversity in Infant Foods in Low-income Neighborhoods Of Kisumu, Kenya

This study examines enteric pathogen contamination in infant foods in low-income neighborhoods of Kisumu, Kenya, finding that cow milk is significantly more likely to contain pathogens than porridge.