Cancer BiologybioRxiv
Antitumor immunity in dMMR colorectal cancers requires interferon-induced CCL5 and CXCL10
C. Mowat, S. R. Mosley, A. Namdar…·K. Baker
This study identifies that dMMR CRCs recruit CD8+ T cells via CCL5 and CXCL10 overexpression driven by cGAS/STING and IFN signaling, offering a therapeutic target for improving immune response in other CRCs.
DOI 10.1084/jem.20210108