Adipose contributes to CXCL5 regulated immune evasion in pancreatic cancer
R. M. Walsh, J. Ambrose, F. Messaggio, B. Bye, A. Eades, J. Jack, M. Ruckert, A. Olou, P. Chalise, D. Pei, M. VanSaun
This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.
bioRxiv · Aug 15, 2023 · PreprintCancer Biology