Author

J. Jack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Eades· 2 shared A. Olou· 2 shared B. Bye· 2 shared M. VanSaun· 2 shared P. Chalise· 2 shared R. M. Walsh· 2 shared A. Pierce· 1 shared D. Pei· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

A. Eades

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Combined PI3K and MAPK inhibition synergizes to suppress PDAC

B. Bye, J. Jack, A. Pierce, R. M. Walsh, A. Eades, A. Olou, P. Chalise, M. VanSaun

This paper shows that combining PI3K and MAPK inhibitors effectively suppresses PDAC by targeting both pathways, with the Omipalisib/Trametinib combination showing the best results in vitro and in vivo.

bioRxiv · Aug 15, 2023 · PreprintCancer Biology

Adipose contributes to CXCL5 regulated immune evasion in pancreatic cancer

R. M. Walsh, J. Ambrose, F. Messaggio, B. Bye, A. Eades, J. Jack, M. Ruckert, A. Olou, P. Chalise, D. Pei, M. VanSaun

This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.

bioRxiv · Aug 15, 2023 · PreprintCancer Biology