R. M. Walsh

The paper determines the structure of BmGr9, an insect gustatory receptor, and compares it to olfactory receptors to understand ligand specificity.

This paper shows that combining PI3K and MAPK inhibitors effectively suppresses PDAC by targeting both pathways, with the Omipalisib/Trametinib combination showing the best results in vitro and in vivo.

This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

The paper reports cryo-EM structures of the SARS-CoV-2 spike protein with the D614G substitution, showing how the mutation affects trimer stability and infectivity.

The paper reports two cryo-EM structures of the SARS-CoV-2 spike protein, showing prefusion and postfusion conformations, and discusses their implications for viral entry and immune evasion.