Cancer BiologybioRxivPreprint
Adipose contributes to CXCL5 regulated immune evasion in pancreatic cancer
R. M. Walsh, J. Ambrose, F. Messaggio…·M. VanSaun
This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.
DOI 10.1101/2023.08.15.553432