Author

F. Otto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 4

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

B. Guigas· 4 shared A. Ozir-Fazalalikhan· 3 shared A. Zawistowska-Deniziak· 3 shared B. Everts· 3 shared E. C. Brombacher· 2 shared H. J. P. van der Zande· 2 shared J. M. Lambooij· 2 shared L. R. Pelgrom· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

B. Guigas

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Author profile →

4 papers

Recent·Most cited

AMPK activation induces RALDHhigh tolerogenic dendritic cells through rewiring of glucose and lipid metabolism

E. C. Brombacher, T. A. Patente, A. J. van der Ham, T. J. A. Moll, F. Otto, F. W. M. Verheijen, E. A. Zaal, A. H. de Ru, R. T. N. Tjokrodirijo, C. R. Berkers, P. A. van Veelen, B. Guigas, B. Everts

This study shows that AMPK activation makes human dendritic cells more tolerogenic by altering their metabolism, specifically increasing RALDH activity and changing lipid and glucose metabolism.

bioRxiv · Jul 4, 2023 · PreprintImmunology

Metabolic sensor AMPK licenses CD103+ dendritic cells to induce Treg responses

T. Patente, E. Brombacher, G. Heieis, L. Pelgrom, A. Zawistowska-Deniziak, F. Otto, A. Ozir-Fazalalikhan, A. van der Ham, B. Guigas, J. A. M. Barbuto, B. Everts

This study shows AMPK is essential for retinoic acid-induced CD103+ dendritic cells to promote Treg responses and control Type 2 immunity.

bioRxiv · Feb 21, 2023 · PreprintImmunology

LKB1 signalling in dendritic cells controls whole-body metabolic homeostasis by limiting T helper 17 priming

H. J. P. van der Zande, E. C. Brombacher, J. M. Lambooij, L. R. Pelgrom, A. Zawistowska-Deniziak, T. A. Patente, G. A. Heieis, F. Otto, A. Ozir-Fazalalikhan, M. Yazdanbakhsh, B. Everts, B. Guigas

This study shows that LKB1 in dendritic cells limits T helper 17 cell priming, thereby protecting against obesity-induced metabolic dysfunctions.

bioRxiv · Oct 14, 2021 · PreprintImmunology

The helminth glycoprotein omega-1 improves metabolic homeostasis in obese mice through type-2 immunity-independent inhibition of food intake

H. J. P. van der Zande, M. A. Gonzalez, K. de Ruiter, R. Wilbers, N. Garcia-Tardon, M. van Huizen, K. van Noort, L. R. Pelgrom, J. M. Lambooij, A. Zawistowska-Deniziak, F. Otto, A. Ozir-Fazalalikhan, D. van Willigen, M. Welling, J. Poles, , B. Guigas

This paper shows that the helminth glycoprotein omega-1 improves metabolic health in obese mice by reducing food intake, independent of type 2 immunity.

bioRxiv · Jul 3, 2020Immunology