Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation
M. Embgenbroich, H. J. van der Zande, L. Hussaarts, J. Schulte-Schrepping, L. R. Pelgrom, N. Garcia-Tardon, L. Schlautmann, I. Stoetzel, K. Handler, J. M. Lambooij, A. Zawistowska-Deniziak, L. Hoving, K. de Ruiter, M. Wijngaarden, H. Pijl, , S. Burgdorf
This study shows that soluble mannose receptor (sMR) promotes pro-inflammatory macrophage activation and metaflammation by inhibiting CD45 phosphatase activity, leading to metabolic dysfunctions in obesity.
bioRxiv · Sep 29, 2020 · PreprintImmunology