Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites
F. Perrin, P. Sinha, S. Mitchell, M. Maesako, O. Berezovska
This study identifies interaction sites between PS1/gamma-secretase and GLT-1 using alanine scanning and FLIM, validated by AlphaFold Multimer, and demonstrates CPPs can disrupt this interaction in neurons.
bioRxiv · May 30, 2023Biochemistry