Author

M. Maesako

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

O. Berezovska· 2 shared A. Becker· 1 shared B. Ozcan· 1 shared C. Hopf· 1 shared D. Gomes Moreira· 1 shared D. Karachentsev· 1 shared F. Perrin· 1 shared K. M. Zoltowska· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

O. Berezovska

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2 papers

Recent·Most cited

Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

K. M. Zoltowska, U. Das, S. Lismont, T. Enzlein, M. Maesako, M. C. Houser, D. Gomes Moreira, M. L. Franco, B. Ozcan, D. Karachentsev, A. Becker, C. Hopf, M. Vilar, O. Berezovska, W. Mobley, L. Chavez-Gutierrez

This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.

bioRxiv · Aug 2, 2023Biochemistry

Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites

F. Perrin, P. Sinha, S. Mitchell, M. Maesako, O. Berezovska

This study identifies interaction sites between PS1/gamma-secretase and GLT-1 using alanine scanning and FLIM, validated by AlphaFold Multimer, and demonstrates CPPs can disrupt this interaction in neurons.

bioRxiv · May 30, 2023Biochemistry