Author

P. Sinha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Cell Biology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:Drosophila· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

A. Bajpai· 3 shared B. Ateeq· 2 shared Q. T. Ahmad· 2 shared R. K. Pandey· 2 shared A. Bruce· 1 shared A. G. Goodman· 1 shared A. Goel· 1 shared A. Thakur· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. Bajpai

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Connecting Transcriptomics with Computational Modeling to Reveal Developmental Adaptations in the Human Pediatric Myocardium

S. Salameh, D. Guerrelli, J. A. Miller, M. Desai, N. Moise, C. Yerebakan, A. Bruce, P. Sinha, Y. d'Udekem, S. H. Weinberg, N. G. Posnack

This study analyzes age-dependent gene expression and electrophysiological changes in pediatric patients with congenital heart disease using computational modeling.

bioRxiv · Apr 19, 2024 · PreprintCell Biology

Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis

C. Mayya, H. Naveena, P. Sinha, D. D. Bhatia

This study identifies dynein's role in galectin-3 mediated clathrin-independent endocytosis, showing its importance for cargo uptake and cell migration.

Journal of Biosciences · Feb 28, 2024Peer-reviewedCell Biology

Hippo effector, Yorkie, is a Tumor Suppressor in Select Drosophila Squamous Epithelia

R. Bhattacharya, J. Kumari, S. Banerjee, J. Tripathi, N. Mohan, P. SINHA

This study shows that Yki signaling suppresses PI3K/Akt/TOR in Drosophila squamous epithelia, preventing tumor formation, and that its loss leads to cancer-like changes in multiple tubular organs.

bioRxiv · Oct 15, 2023 · PreprintCancer Biology

Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites

F. Perrin, P. Sinha, S. Mitchell, M. Maesako, O. Berezovska

This study identifies interaction sites between PS1/gamma-secretase and GLT-1 using alanine scanning and FLIM, validated by AlphaFold Multimer, and demonstrates CPPs can disrupt this interaction in neurons.

bioRxiv · May 30, 2023Biochemistry

Nuclear biocondensate-forming lncRNA and cellular stress surveillance shape host cancer susceptibility

A. Bajpai, Q. T. Ahmad, S. Kundu, R. K. Pandey, A. G. Goodman, A. Goel, B. Ateeq, S. C. Lakhotia, P. Sinha

This study identifies hsr{omega} and its human homologs as key regulators of cancer susceptibility through stress response pathways in Drosophila and humans.

bioRxiv · Apr 26, 2021 · PreprintCancer Biology

A Serpin27A-dependent Toll Signaling Underlies Host Genetics of Cancer Resistance in Drosophila

R. Singh, S. Harsh, A. Bajpai, S. Pal, R. K. Pandey, P. Sinha

This study identifies a Serpin27A-dependent Toll signaling pathway in Drosophila that mediates cancer resistance through NF-κB-mediated tumor cell death.

bioRxiv · Mar 13, 2021 · PreprintCancer Biology

Identification and Optimization of cell active 4-anilino-quin(az)oline Inhibitors for Protein Kinase Novel 3 (PKN3)

C. R. M. Asquith, L. Temme, T. Laitinen, J. Pickett, F. E. Kwarcinski, P. Sinha, C. I. Wells, G. J. Tizzard, R. Zutshi, D. H. Drewry

The paper identifies 7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine as a potent PKN3 inhibitor with an IC50 of 1.3 μM in cells, suggesting its potential as a tool for studying PKN3 biology and therapeutic applications.

bioRxiv · Mar 2, 2020 · PreprintPharmacology & Toxicology

A Drosophila model of oral peptide therapeutics for adult intestinal stem cell tumors

A. Bajpai, Q. T. Ahmad, H.-W. Hong-Wen Tang, N. Manzar, V. Singh, A. Thakur, B. Ateeq, N. Perrimon, P. Sinha

This paper evaluates the efficacy of a TONDU peptide in suppressing Yki-driven intestinal stem cell tumors in Drosophila by inhibiting YAP-TEAD interaction and modulating integrin signaling.

bioRxiv · Jan 21, 2020Cancer Biology