S. Mitchell

The dietary ellagitannin metabolite urolithin A is produced by a molybdenum-dependent dehydroxylase encoded by prevalent human gut Enterocloster spp.

The paper identifies Enterocloster spp. and the ucd operon as key producers of urolithin A from dietary ellagitannins using multi-omics approaches.

Turmeric shortens lifespan in houseflies

This study shows turmeric reduces lifespan in houseflies regardless of diet and sex, with females showing greater body mass at death.

Tumor cell-derived spermidine promotes a pro-tumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites

This study identifies interaction sites between PS1/gamma-secretase and GLT-1 using alanine scanning and FLIM, validated by AlphaFold Multimer, and demonstrates CPPs can disrupt this interaction in neurons.

Integrons, plasmids, and resistance genes in equine faecal bacteria

This study examines how domestication and antimicrobial treatment affect the prevalence of class 1 integrons and antibiotic resistance genes in equine gut bacteria, identifying distinct bacterial taxa and mobile genetic elements associated with these factors.

One Health or Three? Transmission modelling of Klebsiella isolates reveals ecological barriers to transmission between humans, animals and the environment

This study models Klebsiella transmission across human, animal, and environmental sources, finding limited AMR spread outside clinical settings and human-to-human transmission dominance.

Mark-release-recapture of male Aedes aegypti (Diptera: Culicidae): use of rhodamine B to estimate movement, mating and population parameters in preparation for an incompatible male program.

The paper uses mark-release-recapture with rhodamine B to study male Aedes aegypti movement, mating, and population dynamics to inform incompatible insect technique strategies.