The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation
I. Owen, D. Yee, H. Wyne, T. M. Perdikari, V. Johnson, J. Smyth, R. Kortum, N. L. Fawzi, F. Shewmaker
This study shows the FUS-CHOP fusion protein undergoes nuclear liquid-liquid phase separation, forming condensates at super enhancer sites, suggesting a novel oncogenic mechanism in myxoid liposarcoma.
bioRxiv · Feb 24, 2021Cell Biology